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Fabrication and Characterization of Nano-HAp Reinforced Poly-D-L-Iactide Scaffolds with Poly (ethylene glycol) /Dexamethasone Coatings  
Fabrication and Characterization of Nano-HAp Reinforced Poly-D-L-Iactide Scaffolds with Poly (ethylene glycol) /Dexamethasone Coatings
資料類型： PDF文件
關(guān)鍵詞： pdlla/nano-hap  composites  porous  drug  release  shape  memory  
effect  
資料大?。?/td> 107K
所屬學(xué)科： 分子表征
來源： 第六屆亞歐研討會(huì)上處理和性能增強(qiáng)聚合物會(huì)議文集（2013.6.2-6 武漢）
簡介：
Multifunctionalscaffoldscl],whichhavecontrollablebiodegradability,drugdeliveryfunction,andshapememoryeffect,havebeenattractinggreatresearchinterestinthefieldofbonetissueengineeringrecently.Anoveltechniquecombiningwithpolymercoagulation,coldcompressionmoulding,saltparticulateleachingandadrugcoatingmethodhasbeendevelopedtofabricateporouspoly-D-L-lactide/nano-hydroxyapatite(PDLLA/nano-HAp)scaffoldswithpoly(ethyleneglycol)/dexamethasone(PEG/Dex)coatingsC2].Thescaffoldsfabricatedbythistechniquepossesshomogenousporenetworkswithindependentlycontrollableporosityandporesize.Fillingthematrixwithnano-HApparticlescanimprovethemechanicalpropertiesofthecompositescaffolds.ThesurfacehydrophilicityofthescaffoldwasfoundtobeimprovedbyaPEG/Dexcoatingandnano-HApaddition.AninvitrodrugreleasestudyofthePEG/DexcoatedPDLLA/nano-HApscaffoldshasshownthatthedrugreleasebehaviorofthescaffoldscanbeadjustedbyvaryingtheporositylevelandthefilledvolumefractionofthenano-HAp.Apatitecouldbeformedthecompositescaffoldwithnano-HApafterexposuretoasimulatedbodyfluid,leadingtoanimprovementinthebioactivityandapatiteformationabilityofthescaffold.Shapememorypropertiesofthescaffoldshavebeendemonstratedbyshaperecoveryandcyclicthermalmechanicaltests.Theresultsshowthattheshaperecoveryratioandshapefixityrateofthescaffoldsareinfluencedbytheporosity.Moreover,therecoverabilityofthecompositescaffoldsisalsoaffectedbythecontentofthenano-HAp.
作者： L. Ched , C. Y. Tang, C. P. Tsui, D. Z. Chen
上傳時(shí)間： 2013-06-25 13:04:16
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